Jessica Zhang

Senior Associate

2024

Associate

2022 - 2024

Associate

2021 - 2022

Research Scientist

2020 - 2021

• Serve a leading role in developing a second-generation gene-editing platform with CRISPR/Cas9 technology • Conduct and optimize next-generation sequencing (NGS) library preparation • Design and conduct cell-based assays for functional evaluation of Cas9 protein and sgRNA efficiencies • Foster consistent communication with external collaborators and present results both internally and externally

Graduate Student

2015 - 2020

In the laboratory of Prof. Susumu Tonegawa, my research focused on the neuronal mechanisms of emotional behaviors and related psychiatric diseases. - Applied multidisciplinary techniques, including genetics, biochemistry, immunohistochemistry, optogenetics, in vivo calcium imaging, fiber-photometry, behavior assays and data analysis (Matlab, Python) - Co-led a project and dissected genetic-identified neural circuits from the basolateral amygdala (BLA) to central amygdala (CeA) that underly appetitive and aversive behaviors. This study was published in Neuron in 2017. - Led a project and discovered a new neuronal substrate of fear extinction memory in the BLA, providing potential therapeutic targets for the therapeutical treatment of emotional disorders, such as PTSD and general anxiety disorder. This study was published in Neuron in 2020. - Reviewed manuscripts for Journal of Neuroscience and Neuropsychopharmacology. - Participated in MGH Clinical Experience courses on neurodegenerative and neuropsychiatric disorders - Mentored 4 undergraduate students on two research projects and applications for medical school/graduate school. - Volunteered to teach a course on neuroscience and animal behaviors to high school students - Organized the Brain Lunch seminar series and recruited graduate students and postdocs as speakers at the academic year 2017-2018 - As a member of the Graduate student education committee at the MIT BCS Department, participating in organizing the graduate and undergraduate curriculum with department faculty members and administrators - Deliverables: 6 poster presentations; 1 poster award at a prestigious conference of 500+ attendees; 2 publications; 2 invited seminars