Matthew De Silva

Chief Operating Officer

2021

Venture Partner

2021

Builders VC is an early stage $250M fund based in San Francisco focused on investing where technology meets new business models to modernize antiquated industries. I focus on healthcare and life sciences opportunities for the team. https://www.builders.vc

Angel Investor & Syndicate Lead

2021

Longtail Bio Ventures invests across all stages of development (with a bias for seed/series a) in companies built to exploit the intersection of biology and technology. Apply here: https://angel.co/s/matt-desilva/12QtZ Over the past 7 years I've been a founder in the emerging space of technology companies that focus on applying tech startup playbooks and approaches to company building to biology. My company, Notable, is in the precision medicine oncology field. There any many other startups advancing in a similar way in digital health, drug discovery, genomic and proteomic diagnostics, and clinical trial design, to name a few. Prior to starting Notable I was a portfolio manager at Peter Thiel's family office/hedge fund Clarium Capital. Many of these companies build platform-based technologies, which can be partnered with other larger collaborators and/or used to build out an internal set of products or pipeline. These create exciting long term opportunities for angel investors, because they can reduce the binary aspect of traditional life science investing. I have built up many relationships over the years in this space, so it made sense to begin investing as an angel and leading syndicates. As a CEO I benefitted from AngelList syndicates in several of our financing rounds, so I've been on the other side of the table from syndicate leads. This allows me to tailor my approach to be as founder-friendly as possible. I also believe in syndicates as a tool to bring in value-added angels to companies, so please feel free to reach out to me anytime to see if there are ways you think you can help a portfolio company!

Advisor and Angel Investor

2020

Founder & Executive Chairman

2020 - 2023

Founder and CEO

2014 - 2020

Portfolio Manager

2012 - 2014

Analyst

2011 - 2012

Intern

2010 - 2010