Sridhar Ramaswamy

Venture Partner

2021

Investing in early-stage life science companies • Leyden Labs, Board Observer (2021-present) • Invetx, Board Observer (2022-24 / M&A 2024) • Invivyd, Board Observer (2020-21 / IPO 2021)

Entrepreneur In Residence

2019

Biotech company creation • Q1, Inc., Founder & CEO (2020-present) • Q2, Inc., Founder & CEO (2023-present)

Guest Lecturer

2019

• Massachusetts Institute of Technology • Broad Institute of Harvard & MIT • Harvard Business School

Scientific Advisory Board

2018

Senior Vice President & Head, R&D

2016 - 2019

Research & Development, Cancer Therapeutics, Executive Leadership • Built and led a matrix team of 70 drug discovery, translational, and development experts that worked closely with BD, CMC, medical, regulatory, and commercial strategy groups to enable the integrated and externalized discovery, development, and commercialization of a cancer and immuno-oncology pipeline • Directed early pipeline creation through discovery, acquisition, and partnership; early development of new therapeutics from concept through first-in-man studies; and translational science to best position our drugs at the right dose, schedule, and cancer indications so patients most likely benefit • Contributed to small-molecule and antibody discovery, early development, translational biomarker identification & strategy, clinical development & regulatory approval, and commercialization of 11 cancer drugs including niraparib (PARP1/2), dostarlimab (PD1), cobolimab (TIM3), and rolapitant (NK1) for patients with ovarian, prostate, uterine, rectal and other solid tumors • Represented R&D externally with the scientific, medical, regulatory, commercial, and investor communities • Served as a key member of the executive leadership team that led TESARO as a publicly traded, oncology-focused, global biopharmaceutical company and spearheaded its successful acquisition and integration by GSK for $5.1B

Associate Professor of Medicine

2001 - 2019

Medical Oncology & Hematology, Translational & Basic Research, Teaching & Administration • Directed the highly-specialized, multidisciplinary care for patients with breast, GI, and hematologic cancers in both the inpatient and outpatient settings at the Massachusetts General Hospital, Brigham & Women's Hospital, and Dana-Farber Cancer Institute • Founded and directed a highly-influential, NIH-funded, multidisciplinary research program focused on understanding how human carcinomas grow and progress from localized cancers, via circulating tumors cells, into advanced, metastatic, dormant, and treatment-resistant disease (h-index = 73) • Developed cancer systems biology approaches to study human tumors as complex, adaptive, multi-scale systems • Disseminated many tools, methods, and approaches invented by my research group to the worldwide cancer research, translational medicine, and drug development communities • Taught a generation of medical & graduate students, interns & residents, and clinical & research fellows in the classroom, at the bench, and the bedside.

MGH / Samana Cay Endowed Investigator

2015 - 2017

Cancer Biology & Therapeutics, Translational & Basic Research, Teaching, Administration

Director, Center for Computational Biology

2004 - 2017

Integrative, Systems, & Computational Biology, Bioinformatics, Data Science

Tucker Gosnell Investigator

2004 - 2017

Medical Oncology, Cancer Biology & Therapeutics, Translational & Basic Research, Teaching, Administration

Principal Investigator, Center for Cancer Research

2004 - 2017

Patient-oriented laboratory research

Attending Physician in Medicine & Cancer Center

2000 - 2017

Medical Oncology, Hematology, Internal Medicine

Associate Member

2006 - 2017

Genetics & Genomics, Systems Biology, Data Science

Principal Member

2006 - 2017

Stem Cell Biology, Regenerative Medicine

Associate Member

2006 - 2017

Cancer Biology, Cancer Therapeutics & Diagnostics

Attending Physician in Medicine

2001 - 2004

Medical Oncology, Therapeutics, & Diagnostics, Translational & Basic Research, Cancer Biology, Teaching

Attending Physician in Medicine

2001 - 2004

Medical Oncology, Therapeutics, & Diagnostics, Translational & Basic Research, Cancer Biology, Teaching