VR

Victor Rusu

Principal at Apple Tree Partners

Greater Boston

Invests in

Stages:

  • Min Investment:

    $100,000.00
  • Max Investment:

    $5,000,000.00
  • Target Investment:

    $1,500,000.00

Work Experience

  • Principal

    2019

2018 - 2019

  • Senior Biotechnology Associate at Citi

    2018 - 2019

2017 - 2018

  • Senior Scientist

    2017 - 2018

2012 - 2017

  • PhD Graduate Student

    2012 - 2017

    - Identified molecular mechanisms through which mutations in a previously uncharacterized gene, SLC16A11, increase type 2 diabetes (T2D) risk. These mutations are among the largest known T2D risk factors. - Characterized function of SLC16A11 and impact of T2D-associated mutations using unbiased methods: metabolomics, RNA-sequencing, proteomics, and ChIP-sequencing. - Used targeted biochemical assays to demonstrate the impact of T2D-associated coding mutations on SLC16A11 binding to a chaperone protein and the resulting effects on cellular localization. - Used gene expression studies, allelic imbalance assays, and reporters to investigate impact of T2D-associated noncoding mutations on SLC16A11 gene regulation. - Performed functional experiments in primary human hepatocytes investing role of SLC16A11 in metabolism.