YN

Yajie Niu

Building companies to transform agriculture for a sustainable future

Cambridge, Massachusetts

Invests in

Stages:

  • Min Investment:

    $500,000.00
  • Max Investment:

    $15,000,000.00
  • Target Investment:

    $7,000,000.00

Work Experience

2020

  • Chief Science Officer

    2023

  • Head of Technologies

    2022 - 2023

  • Head of External Technologies Innovation

    2022 - 2022

  • Head Of Research

    2020 - 2022

2019 - 2022

  • Principal

    2021 - 2022

  • Senior Associate

    2019 - 2021

2017 - 2019

  • Senior Director of Research Development

    2017 - 2019

    • Developed proprietary CRISPR tools for gene modulation • Developed and implemented high-throughput cell screening platform that enables fast validation and discovery of target leads • Implemented next generation sequencing and data analysis pipeline for efficient molecular readout and phenotyping • Supported technology and products intellectual property development

  • Director Of Research Development

    2017 - 2017

2016 - 2017

  • Senior Scientist

    2016 - 2017

  • Research Fellow

    2009 - 2016

    Employed integrative and novel approaches in molecular biology, functional genomics, chemical genetics, biochemistry and computational biology to: • Design and develop methodologies in calcium imaging, including construction of an ultrasensitive Ca2+ biosensor GCaMP6S and development of a leaf single-cell system for live GCaMP6S-based Ca2+ imaging • Uncover a unique temporal Ca2+ signal in nutrient signaling pathway • Develop and optimize cell-based functional genomic screen to identify different Ca2+ sensor kinases in plant immune, hormone, stress and nutrient signaling pathways • Apply protein engineering and chemical genetics to circumvent embryo lethality and functional redundancy of Ca2+ sensor kinases • Develop and optimize artificial miRNA gene-silencing, RNA-seq, MS phosphoproteomics to link Ca2+ sensor kinases to diverse intracellular effectors